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<title>Crossover study</title>

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<span id="openzim-page-title" class="mw-page-title-main"><span class="mw-page-title-main">Crossover study</span></span>

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</style><div role="note" class="hatnote navigation-not-searchable">"Crossover experiment" redirects here. For the chemical reaction/mechanism analysis, see <a href="Crossover_experiment_(chemistry)" title="Crossover experiment (chemistry)">crossover experiment (chemistry)</a>.</div>

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<p>In <a href="Medicine" title="Medicine">medicine</a>, a <b>crossover study</b> or <b>crossover trial</b> is a <a href="Longitudinal_study" title="Longitudinal study">longitudinal study</a> in which <a href="Human_subject_research" title="Human subject research">subjects</a> receive a sequence of different <a href="Medical_case_management" title="Medical case management">treatments</a> (or exposures). While crossover studies can be <a href="Observational_studies" class="mw-redirect" title="Observational studies">observational studies</a>, many important crossover studies are <a href="Controlled_experiment" class="mw-redirect" title="Controlled experiment">controlled experiments</a>, which are discussed in this article. Crossover designs are common for experiments in many <a href="Scientific_discipline" class="mw-redirect" title="Scientific discipline">scientific disciplines</a>, for example <a href="Psychology#Research_methods" title="Psychology">psychology</a>, <a href="Pharmaceutical_science" class="mw-redirect" title="Pharmaceutical science">pharmaceutical science</a>, and medicine.

</p><p><a href="Randomization" title="Randomization">Randomized</a>, controlled crossover experiments are especially important in health care. In a randomized <a href="Clinical_trial" title="Clinical trial">clinical trial</a>, the subjects are <a href="Random_assignment" title="Random assignment">randomly assigned</a> to different arms of the study which receive different treatments. When the trial has a <a href="Repeated_measures_design" title="Repeated measures design">repeated measures design</a>, the same measures are collected multiple times for each subject. A crossover trial has a repeated measures design in which each <a href="Patient" title="Patient">patient</a> is assigned to a sequence of two or more treatments, of which one may be a <a href="Standard_treatment" title="Standard treatment">standard treatment</a> or a <a href="Placebo" title="Placebo">placebo</a>.

</p><p>Nearly all crossover are designed to have "balance", whereby all subjects receive the same number of treatments and participate for the same number of periods. In most crossover trials each subject receives all treatments, in a random order.

</p><p>Statisticians suggest that designs should have four periods, which is more efficient than the two-period design, even if the study must be truncated to three periods.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> However, the two-period design is often taught in non-statistical textbooks, partly because of its simplicity.

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<div class="mw-heading mw-heading2"><h2 id="Analysis">Analysis</h2></div>

<p>The data is analyzed using the <a href="Statistical_inference" title="Statistical inference">statistical method</a> that was specified in the <a href="Clinical_trial_protocol" class="mw-redirect" title="Clinical trial protocol">clinical trial protocol</a>, which must have been approved by the appropriate <a href="Institutional_review_board" title="Institutional review board">institutional review boards</a> and <a href="Regulatory_agency" title="Regulatory agency">regulatory agencies</a> before the trial can begin. Most clinical trials are analyzed using repeated-measurements ANOVA (<a href="Analysis_of_variance" title="Analysis of variance">analysis of variance</a>) or <a href="Mixed_model" title="Mixed model">mixed models</a> that include <a href="Random_effect" class="mw-redirect" title="Random effect">random effects</a>.

</p><p>In most longitudinal studies of human subjects, <a href="Patients" class="mw-redirect" title="Patients">patients</a> may withdraw from the trial or become "<a href="Lost_to_follow-up" title="Lost to follow-up">lost to follow-up</a>". There are statistical methods for dealing with such <a href="Missing_data" title="Missing data">missing-data</a> and "<a href="Censoring_(statistics)" title="Censoring (statistics)">censoring</a>" problems. An important method analyzes the data according to the principle of the <a href="Intention_to_treat_analysis" class="mw-redirect" title="Intention to treat analysis">intention to treat</a>.

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<div class="mw-heading mw-heading2"><h2 id="Advantages">Advantages</h2></div>

<p>A crossover study has two advantages over both a <a href="Parallel_study" title="Parallel study">parallel study</a> and a non-crossover <a href="Longitudinal_study" title="Longitudinal study">longitudinal study</a>. First, the influence of <a href="Confounding_variable" class="mw-redirect" title="Confounding variable">confounding</a> <a href="Covariate" class="mw-redirect" title="Covariate">covariates</a> is reduced because each crossover patient serves as their own <a href="Scientific_control" title="Scientific control">control</a>.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> In a randomized non-crossover study it is often the case that different treatment-groups are found to be unbalanced on some covariates. In a controlled, <a href="Randomized" class="mw-redirect" title="Randomized">randomized</a> crossover designs, such imbalances are implausible (unless <a href="Time-varying_covariate" title="Time-varying covariate">covariates were to change</a> systematically during the study).

</p><p>Second, <a href="Optimal_design" class="mw-redirect" title="Optimal design">optimal</a> crossover designs are <a href="Efficiency_(statistics)" title="Efficiency (statistics)">statistically efficient</a>, and so require fewer subjects than do non-crossover designs (even other repeated measures designs).

</p><p>Optimal crossover designs are discussed in the graduate textbook by Jones and Kenward and in the review article by Stufken. Crossover designs are discussed along with more general repeated-measurements designs in the graduate textbook by Vonesh and Chinchilli.

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<div class="mw-heading mw-heading2"><h2 id="Limitations_and_disadvantages">Limitations and disadvantages</h2></div>

<p>These studies are often done to improve the symptoms of patients with <a href="Chronic_(medicine)" class="mw-redirect" title="Chronic (medicine)">chronic conditions</a>. For curative treatments or rapidly changing conditions, cross-over trials may be infeasible or unethical.

</p><p>Crossover studies often have two problems:

</p><p>First is the issue of <a href="Repeated_measures_design#Order_effects" title="Repeated measures design">"order" effects</a>, because it is possible that the order in which treatments are administered may affect the outcome. An example might be a drug with many adverse effects given first, making patients taking a second, less harmful medicine, more sensitive to any adverse effect.

</p><p>Second is the issue of "carry-over" between treatments, which <a href="Confounding" title="Confounding">confounds</a> the <a href="Estimates" title="Estimates">estimates</a> of the <a href="Effect_size" title="Effect size">treatment effects</a>. In practice, "carry-over" effects can be avoided with a sufficiently long "wash-out" period between treatments. However, planning for sufficiently long wash-out periods requires expert knowledge of the <a href="Psychodynamics" title="Psychodynamics">dynamics</a> of the treatment, which is often unknown.

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<ul><li><a href="Design_of_experiments" title="Design of experiments">Design of experiments</a></li>

<li><a href="Glossary_of_experimental_design" title="Glossary of experimental design">Glossary of experimental design</a></li>

<li><a href="Randomized_controlled_trial" title="Randomized controlled trial">Randomized controlled trial</a></li>

<li><a href="Survival_analysis" title="Survival analysis">Survival analysis</a></li>

<li><a href="N_of_1_trial" class="mw-redirect" title="N of 1 trial">N of 1 trial</a></li>

<li><a href="Single-subject_design" title="Single-subject design">Single-subject design</a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="Notes">Notes</h2></div>

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<li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text">Vonesh & Chinchilli (1997)</span>

</li>

<li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text">Jones & Kenward (2003)</span>

</li>

<li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text">Jones, B., & Kenward, M. G. (2003). Design and analysis of cross-over trials (2nd ed.). Boca Raton, Fla.: Chapman & Hall/CRC.</span>

</li>

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<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

<ul><li>M. Bose and A. Dey (2009). <i>Optimal Crossover Designs</i>. World Scientific. <style data-mw-deduplicate="TemplateStyles:r1238218222">

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</style><a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-9812818423</bdi></li>

<li>D. E. Johnson (2010). Crossover experiments. <i>WIREs Comp Stat</i>, 2: 620-625. <a rel="nofollow" class="external autonumber" href="http://onlinelibrary.wiley.com/doi/10.1002/wics.109/abstract">[1]</a></li>

<li><cite id="CITEREFJonesKenward,_Michael_G.2014" class="citation book cs1">Jones, Byron; Kenward, Michael G. (2014). <i>Design and Analysis of Cross-Over Trials</i> (Third ed.). London: Chapman and Hall. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-0412606403</bdi>.</cite><span class="cs1-maint citation-comment"><code class="cs1-code">{{cite book}}</code>: CS1 maint: publisher location (link)</span></li>

<li>K.-J. Lui, (2016). <i>Crossover Designs: Testing, Estimation, and Sample Size</i>. Wiley.</li>

<li>Najafi Mehdi, (2004). <i>Statistical Questions in Evidence Based Medicine</i>. New York: Oxford University Press. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>0-19-262992-1</bdi></li>

<li>D. Raghavarao and L. Padgett (2014). <i>Repeated Measurements and Cross-Over Designs.</i> Wiley. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-1-118-70925-2</bdi></li>

<li>D. A. Ratkowsky, M. A. Evans, and J. R. Alldredge (1992). <i>Cross-Over Experiments: Design, Analysis, and Application.</i> Marcel Dekker. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-0824788926</bdi></li>

<li>Senn, S. (2002). <i>Cross-Over Trials in Clinical Research,</i> Second edition. Wiley. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-0-471-49653-3</bdi></li>

<li><cite id="CITEREFStufken,_J.1996" class="citation book cs1">Stufken, J. (1996). "Optimal Crossover Designs". In Ghosh, S.; <a href="Calyampudi_Radhakrishna_Rao" class="mw-redirect" title="Calyampudi Radhakrishna Rao">Rao, C. R.</a> (eds.). <i>Design and Analysis of Experiments</i>. Handbook of Statistics. Vol. 13. North-Holland. pp. <span class="nowrap">63–</span>90. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-0-444-82061-7</bdi>.</cite></li>

<li><cite id="CITEREFVoneshChinchilli1997" class="citation book cs1">Vonesh, Edward F.; Chinchilli, Vernon G. (1997). "Crossover Experiments". <i>Linear and Nonlinear Models for the Analysis of Repeated Measurements</i>. London: Chapman and Hall. pp. <span class="nowrap">111–</span>202. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-0824782481</bdi>.</cite><span class="cs1-maint citation-comment"><code class="cs1-code">{{cite book}}</code>: CS1 maint: publisher location (link)</span></li></ul>

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</style><div id="Design_of_experiments708" style="font-size:114%;margin:0 4em"><a href="Design_of_experiments" title="Design of experiments">Design of experiments</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Scientific_method" title="Scientific method">Scientific<br>method</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Experiment" title="Experiment">Scientific experiment</a></li>

<li><a href="Design_of_experiments" title="Design of experiments">Statistical design</a></li>

<li><a href="Scientific_control" title="Scientific control">Control</a></li>

<li><a href="Internal_validity" title="Internal validity">Internal</a> and <a href="External_validity" title="External validity">external</a> <a href="Validity_(statistics)" title="Validity (statistics)">validity</a></li>

<li><a href="Experimental_unit" class="mw-redirect" title="Experimental unit">Experimental unit</a></li>

<li><a href="Blind_experiment" class="mw-redirect" title="Blind experiment">Blinding</a></li></ul>

<ul><li><b><a href="Optimal_design" class="mw-redirect" title="Optimal design">Optimal design</a></b>: <a href="Bayesian_experimental_design" title="Bayesian experimental design">Bayesian</a></li>

<li><a href="Random_assignment" title="Random assignment">Random assignment</a></li>

<li><a href="Randomization" title="Randomization">Randomization</a></li>

<li><a href="Restricted_randomization" title="Restricted randomization">Restricted randomization</a></li>

<li><a href="Replication_(statistics)" title="Replication (statistics)">Replication versus subsampling</a></li>

<li><a href="Sample_size" class="mw-redirect" title="Sample size">Sample size</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Glossary_of_experimental_design" title="Glossary of experimental design">Treatment</a><br> and <a href="Blocking_(statistics)" title="Blocking (statistics)">blocking</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><b><a href="Glossary_of_experimental_design" title="Glossary of experimental design">Treatment</a></b></li>

<li><a href="Effect_size" title="Effect size">Effect size</a></li>

<li><a href="Contrast_(statistics)" title="Contrast (statistics)">Contrast</a></li>

<li><a href="Interaction_(statistics)" title="Interaction (statistics)">Interaction</a></li>

<li><a href="Confounding" title="Confounding">Confounding</a></li>

<li><a href="Orthogonality#Statistics,_econometrics,_and_economics" title="Orthogonality">Orthogonality</a></li>

<li><b><a href="Blocking_(statistics)" title="Blocking (statistics)">Blocking</a></b></li>

<li><a href="Covariate" class="mw-redirect" title="Covariate">Covariate</a></li>

<li><a href="Nuisance_variable" title="Nuisance variable">Nuisance variable</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Statistical_model" title="Statistical model">Models</a> <br> and <a href="Statistical_inference" title="Statistical inference">inference</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Linear_regression" title="Linear regression">Linear regression</a></li>

<li><a href="Ordinary_least_squares" title="Ordinary least squares">Ordinary least squares</a></li>

<li><a href="Bayesian_linear_regression" title="Bayesian linear regression">Bayesian</a></li></ul>

<ul><li><b><a href="Random_effect" class="mw-redirect" title="Random effect">Random effect</a></b></li>

<li><a href="Mixed_model" title="Mixed model">Mixed model</a></li>

<li><a href="Hierarchical_linear_modeling" class="mw-redirect" title="Hierarchical linear modeling">Hierarchical model:</a> <a href="Hierarchical_Bayes_model" class="mw-redirect" title="Hierarchical Bayes model">Bayesian</a></li></ul>

<ul><li><b><a href="Analysis_of_variance" title="Analysis of variance">Analysis of variance (Anova)</a></b></li>

<li><a href="Cochran's_theorem" title="Cochran's theorem">Cochran's theorem</a></li>

<li><a href="Multivariate_analysis_of_variance" title="Multivariate analysis of variance"><b>Manova</b> (<i>multivariate</i>)</a></li>

<li><a href="Analysis_of_covariance" title="Analysis of covariance"><b>Ancova</b> (<i>covariance</i>)</a></li></ul>

<ul><li><a href="Comparing_means" class="mw-redirect" title="Comparing means">Compare means</a></li>

<li><a href="Multiple_comparison" class="mw-redirect" title="Multiple comparison">Multiple comparison</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Design_of_experiments" title="Design of experiments">Designs</a> <br> <br><a href="Completely_randomized_design" title="Completely randomized design">Completely<br>randomized</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><b><a href="Factorial_experiment" title="Factorial experiment">Factorial</a></b></li>

<li><a href="Fractional_factorial_design" title="Fractional factorial design">Fractional factorial</a></li>

<li><a href="Plackett-Burman_design" class="mw-redirect" title="Plackett-Burman design">Plackett–Burman</a></li>

<li><a href="Taguchi_methods" title="Taguchi methods">Taguchi</a></li></ul>

<ul><li><b><a href="Response_surface_methodology" title="Response surface methodology">Response surface methodology</a></b></li>

<li><a href="Polynomial_and_rational_function_modeling" title="Polynomial and rational function modeling">Polynomial and rational modeling</a></li>

<li><a href="Box%E2%80%93Behnken_design" title="Box–Behnken design">Box–Behnken</a></li>

<li><a href="Central_composite_design" title="Central composite design">Central composite</a></li></ul>

<ul><li><b><a href="Randomized_block_design" class="mw-redirect" title="Randomized block design">Block</a></b></li>

<li><a href="Generalized_randomized_block_design" title="Generalized randomized block design">Generalized randomized block design</a> (GRBD)</li>

<li><a href="Latin_square" title="Latin square">Latin square</a></li>

<li><a href="Graeco-Latin_square" class="mw-redirect" title="Graeco-Latin square">Graeco-Latin square</a></li>

<li><a href="Orthogonal_array" title="Orthogonal array">Orthogonal array</a></li>

<li><a href="Latin_hypercube_sampling" title="Latin hypercube sampling">Latin hypercube</a> <br> <b><a href="Repeated_measures_design" title="Repeated measures design">Repeated measures design</a></b></li>

</ul>

<ul><li><b><a href="Randomized_controlled_trial" title="Randomized controlled trial">Randomized controlled trial</a></b></li>

<li><a href="Sequential_analysis" title="Sequential analysis">Sequential analysis</a></li>

<li><a href="Sequential_probability_ratio_test" title="Sequential probability ratio test">Sequential probability ratio test</a></li></ul>

</div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>

<ul><li><a href="Glossary_of_experimental_design" title="Glossary of experimental design">Glossary</a></li>

<li>Category</li>

<li><span class="nowrap"><span class="skin-invert-image noviewer" typeof="mw:File"></span> </span><a href="Portal%3AMathematics" title="Portal:Mathematics">Mathematics portal</a></li>

<li><a href="Outline_of_statistics" title="Outline of statistics">Statistical outline</a></li>

<li><a href="List_of_statistics_articles" title="List of statistics articles">Statistical topics</a></li></ul>

</div></td></tr></tbody></table></div>

<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Statistics654" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Statistics654" style="font-size:114%;margin:0 4em"><a href="Statistics" title="Statistics">Statistics</a></div></th></tr><tr><td class="navbox-abovebelow" colspan="2"><div>

<ul><li><a href="Outline_of_statistics" title="Outline of statistics">Outline</a></li>

<li><a href="List_of_statistics_articles" title="List of statistics articles">Index</a></li></ul>

</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Descriptive_statistics654" style="font-size:114%;margin:0 4em"><a href="Descriptive_statistics" title="Descriptive statistics">Descriptive statistics</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Continuous_probability_distribution" class="mw-redirect" title="Continuous probability distribution">Continuous data</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Central_tendency" title="Central tendency">Center</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Arithmetic_mean" title="Arithmetic mean">Arithmetic</a></li>

<li><a href="Arithmetic%E2%80%93geometric_mean" title="Arithmetic–geometric mean">Arithmetic-Geometric</a></li>

<li><a href="Contraharmonic_mean" title="Contraharmonic mean">Contraharmonic</a></li>

<li><a href="Cubic_mean" title="Cubic mean">Cubic</a></li>

<li><a href="Generalized_mean" title="Generalized mean">Generalized/power</a></li>

<li><a href="Geometric_mean" title="Geometric mean">Geometric</a></li>

<li><a href="Harmonic_mean" title="Harmonic mean">Harmonic</a></li>

<li><a href="Heronian_mean" title="Heronian mean">Heronian</a></li>

<li><a href="Heinz_mean" title="Heinz mean">Heinz</a></li>

<li><a href="Lehmer_mean" title="Lehmer mean">Lehmer</a></li></ul></li>

<li><a href="Median" title="Median">Median</a></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Statistical_dispersion" title="Statistical dispersion">Dispersion</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Average_absolute_deviation" title="Average absolute deviation">Average absolute deviation</a></li>

<li><a href="Coefficient_of_variation" title="Coefficient of variation">Coefficient of variation</a></li>

<li><a href="Interquartile_range" title="Interquartile range">Interquartile range</a></li>

<li><a href="Percentile" title="Percentile">Percentile</a></li>

<li><a href="Range_(statistics)" title="Range (statistics)">Range</a></li>

<li><a href="Standard_deviation" title="Standard deviation">Standard deviation</a></li>

<li><a href="Variance#Sample_variance" title="Variance">Variance</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Shape_of_the_distribution" class="mw-redirect" title="Shape of the distribution">Shape</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Central_limit_theorem" title="Central limit theorem">Central limit theorem</a></li>

<li><a href="Moment_(mathematics)" title="Moment (mathematics)">Moments</a>

<ul><li><a href="Kurtosis" title="Kurtosis">Kurtosis</a></li>

<li><a href="L-moment" title="L-moment">L-moments</a></li>

<li><a href="Skewness" title="Skewness">Skewness</a></li></ul></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Count_data" title="Count data">Count data</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Index_of_dispersion" title="Index of dispersion">Index of dispersion</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em">Summary tables</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Contingency_table" title="Contingency table">Contingency table</a></li>

<li><a href="Frequency_distribution" class="mw-redirect" title="Frequency distribution">Frequency distribution</a></li>

<li><a href="Grouped_data" title="Grouped data">Grouped data</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Correlation_and_dependence" class="mw-redirect" title="Correlation and dependence">Dependence</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Partial_correlation" title="Partial correlation">Partial correlation</a></li>

<li><a href="Pearson_correlation_coefficient" title="Pearson correlation coefficient">Pearson product-moment correlation</a></li>

<li><a href="Rank_correlation" title="Rank correlation">Rank correlation</a>

<ul><li><a href="Kendall_rank_correlation_coefficient" title="Kendall rank correlation coefficient">Kendall's τ</a></li>

<li><a href="Spearman's_rank_correlation_coefficient" title="Spearman's rank correlation coefficient">Spearman's ρ</a></li></ul></li>

<li><a href="Scatter_plot" title="Scatter plot">Scatter plot</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Statistical_graphics" title="Statistical graphics">Graphics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Bar_chart" title="Bar chart">Bar chart</a></li>

<li><a href="Biplot" title="Biplot">Biplot</a></li>

<li><a href="Control_chart" title="Control chart">Control chart</a></li>

<li><a href="Correlogram" title="Correlogram">Correlogram</a></li>

<li><a href="Fan_chart_(statistics)" title="Fan chart (statistics)">Fan chart</a></li>

<li><a href="Forest_plot" title="Forest plot">Forest plot</a></li>

<li><a href="Histogram" title="Histogram">Histogram</a></li>

<li><a href="Pie_chart" title="Pie chart">Pie chart</a></li>

<li><a href="Radar_chart" title="Radar chart">Radar chart</a></li>

<li><a href="Run_chart" title="Run chart">Run chart</a></li>

<li><a href="Scatter_plot" title="Scatter plot">Scatter plot</a></li>

<li><a href="Stem-and-leaf_display" title="Stem-and-leaf display">Stem-and-leaf display</a></li>

<li><a href="Violin_plot" title="Violin plot">Violin plot</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Data_collection654" style="font-size:114%;margin:0 4em"><a href="Data_collection" title="Data collection">Data collection</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Design_of_experiments" title="Design of experiments">Study design</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Effect_size" title="Effect size">Effect size</a></li>

<li><a href="Missing_data" title="Missing data">Missing data</a></li>

<li><a href="Optimal_design" class="mw-redirect" title="Optimal design">Optimal design</a></li>

<li><a href="Statistical_population" title="Statistical population">Population</a></li>

<li><a href="Replication_(statistics)" title="Replication (statistics)">Replication</a></li>

<li><a href="Sample_size_determination" title="Sample size determination">Sample size determination</a></li>

<li><a href="Statistic" title="Statistic">Statistic</a></li>

<li><a href="Statistical_power" class="mw-redirect" title="Statistical power">Statistical power</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Survey_methodology" title="Survey methodology">Survey methodology</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Sampling_(statistics)" title="Sampling (statistics)">Sampling</a>

<ul><li><a href="Cluster_sampling" title="Cluster sampling">Cluster</a></li>

<li><a href="Stratified_sampling" title="Stratified sampling">Stratified</a></li></ul></li>

<li><a href="Opinion_poll" title="Opinion poll">Opinion poll</a></li>

<li><a href="Questionnaire" title="Questionnaire">Questionnaire</a></li>

<li><a href="Standard_error" title="Standard error">Standard error</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Experiment" title="Experiment">Controlled experiments</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Blocking_(statistics)" title="Blocking (statistics)">Blocking</a></li>

<li><a href="Factorial_experiment" title="Factorial experiment">Factorial experiment</a></li>

<li><a href="Interaction_(statistics)" title="Interaction (statistics)">Interaction</a></li>

<li><a href="Random_assignment" title="Random assignment">Random assignment</a></li>

<li><a href="Randomized_controlled_trial" title="Randomized controlled trial">Randomized controlled trial</a></li>

<li><a href="Randomized_experiment" title="Randomized experiment">Randomized experiment</a></li>

<li><a href="Scientific_control" title="Scientific control">Scientific control</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em">Adaptive designs</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Adaptive_clinical_trial" class="mw-redirect" title="Adaptive clinical trial">Adaptive clinical trial</a></li>

<li><a href="Stochastic_approximation" title="Stochastic approximation">Stochastic approximation</a></li>

<li><a href="Up-and-Down_Designs" class="mw-redirect" title="Up-and-Down Designs">Up-and-down designs</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Observational_study" title="Observational study">Observational studies</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cohort_study" title="Cohort study">Cohort study</a></li>

<li><a href="Cross-sectional_study" title="Cross-sectional study">Cross-sectional study</a></li>

<li><a href="Natural_experiment" title="Natural experiment">Natural experiment</a></li>

<li><a href="Quasi-experiment" title="Quasi-experiment">Quasi-experiment</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Statistical_inference654" style="font-size:114%;margin:0 4em"><a href="Statistical_inference" title="Statistical inference">Statistical inference</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Statistical_theory" title="Statistical theory">Statistical theory</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Population_(statistics)" class="mw-redirect" title="Population (statistics)">Population</a></li>

<li><a href="Statistic" title="Statistic">Statistic</a></li>

<li><a href="Probability_distribution" title="Probability distribution">Probability distribution</a></li>

<li><a href="Sampling_distribution" title="Sampling distribution">Sampling distribution</a>

<ul><li><a href="Order_statistic" title="Order statistic">Order statistic</a></li></ul></li>

<li><a href="Empirical_distribution_function" title="Empirical distribution function">Empirical distribution</a>

<ul><li><a href="Density_estimation" title="Density estimation">Density estimation</a></li></ul></li>

<li><a href="Statistical_model" title="Statistical model">Statistical model</a>

<ul><li><a href="Model_specification" class="mw-redirect" title="Model specification">Model specification</a></li>

<li><a href="Lp_space" title="Lp space">L<sup><i>p</i></sup> space</a></li></ul></li>

<li><a href="Statistical_parameter" title="Statistical parameter">Parameter</a>

<ul><li><a href="Location_parameter" title="Location parameter">location</a></li>

<li><a href="Scale_parameter" title="Scale parameter">scale</a></li>

<li><a href="Shape_parameter" title="Shape parameter">shape</a></li></ul></li>

<li><a href="Parametric_statistics" title="Parametric statistics">Parametric family</a>

<ul><li><a href="Likelihood_function" title="Likelihood function">Likelihood</a> <a href="Monotone_likelihood_ratio" title="Monotone likelihood ratio"><span style="font-size: 85%;">(monotone)</span></a></li>

<li><a href="Location%E2%80%93scale_family" title="Location–scale family">Location–scale family</a></li>

<li><a href="Exponential_family" title="Exponential family">Exponential family</a></li></ul></li>

<li><a href="Completeness_(statistics)" title="Completeness (statistics)">Completeness</a></li>

<li><a href="Sufficient_statistic" title="Sufficient statistic">Sufficiency</a></li>

<li><a href="Plug-in_principle" class="mw-redirect" title="Plug-in principle">Statistical functional</a>

<ul><li><a href="Bootstrapping_(statistics)" title="Bootstrapping (statistics)">Bootstrap</a></li>

<li><a href="Optimal_decision" title="Optimal decision">Optimal decision</a>

<ul><li><a href="Loss_function" title="Loss function">loss function</a></li></ul></li>

<li><a href="Efficiency_(statistics)" title="Efficiency (statistics)">Efficiency</a></li>

<li><a href="Statistical_distance" title="Statistical distance">Statistical distance</a>

<ul><li><a href="Divergence_(statistics)" title="Divergence (statistics)">divergence</a></li></ul></li>

<li><a href="Asymptotic_theory_(statistics)" title="Asymptotic theory (statistics)">Asymptotics</a></li>

<li><a href="Robust_statistics" title="Robust statistics">Robustness</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Frequentist_inference" title="Frequentist inference">Frequentist inference</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Point_estimation" title="Point estimation">Point estimation</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Estimating_equations" title="Estimating equations">Estimating equations</a>

<ul><li><a href="Maximum_likelihood" class="mw-redirect" title="Maximum likelihood">Maximum likelihood</a></li>

<li><a href="Method_of_moments_(statistics)" title="Method of moments (statistics)">Method of moments</a></li>

<li><a href="M-estimator" title="M-estimator">M-estimator</a></li>

<li><a href="Minimum_distance_estimation" class="mw-redirect" title="Minimum distance estimation">Minimum distance</a></li></ul></li>

<li><a href="Bias_of_an_estimator" title="Bias of an estimator">Unbiased estimators</a>

<ul><li><a href="Minimum-variance_unbiased_estimator" title="Minimum-variance unbiased estimator">Mean-unbiased minimum-variance</a>

<ul><li><a href="Rao%E2%80%93Blackwell_theorem" title="Rao–Blackwell theorem">Rao–Blackwellization</a></li>

<li><a href="Lehmann%E2%80%93Scheff%C3%A9_theorem" title="Lehmann–Scheffé theorem">Lehmann–Scheffé theorem</a></li></ul></li>

<li><a href="Median-unbiased_estimator" class="mw-redirect" title="Median-unbiased estimator">Median unbiased</a></li></ul></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Interval_estimation" title="Interval estimation">Interval estimation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Confidence_interval" title="Confidence interval">Confidence interval</a></li>

<li><a href="Pivotal_quantity" title="Pivotal quantity">Pivot</a></li>

<li><a href="Likelihood_interval" class="mw-redirect" title="Likelihood interval">Likelihood interval</a></li>

<li><a href="Prediction_interval" title="Prediction interval">Prediction interval</a></li>

<li><a href="Tolerance_interval" title="Tolerance interval">Tolerance interval</a></li>

<li><a href="Resampling_(statistics)" title="Resampling (statistics)">Resampling</a>

<ul><li><a href="Bootstrapping_(statistics)" title="Bootstrapping (statistics)">Bootstrap</a></li>

<li><a href="Jackknife_resampling" title="Jackknife resampling">Jackknife</a></li></ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Statistical_hypothesis_testing" class="mw-redirect" title="Statistical hypothesis testing">Testing hypotheses</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="One-_and_two-tailed_tests" title="One- and two-tailed tests">1- & 2-tails</a></li>

<li><a href="Power_(statistics)" title="Power (statistics)">Power</a>

<ul><li><a href="Uniformly_most_powerful_test" title="Uniformly most powerful test">Uniformly most powerful test</a></li></ul></li>

<li><a href="Permutation_test" title="Permutation test">Permutation test</a>

<ul><li><a href="Randomization_test" class="mw-redirect" title="Randomization test">Randomization test</a></li></ul></li>

<li><a href="Multiple_comparisons" class="mw-redirect" title="Multiple comparisons">Multiple comparisons</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Parametric_statistics" title="Parametric statistics">Parametric tests</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Likelihood-ratio_test" title="Likelihood-ratio test">Likelihood-ratio</a></li>

<li><a href="Score_test" title="Score test">Score/Lagrange multiplier</a></li>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="List_of_statistical_tests" title="List of statistical tests">Specific tests</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Z-test" title="Z-test"><i>Z</i>-test <span style="font-size: 85%;">(normal)</span></a></li>

<li><a href="Student's_t-test" title="Student's t-test">Student's <i>t</i>-test</a></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Goodness_of_fit" title="Goodness of fit">Goodness of fit</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Chi-squared_test" title="Chi-squared test">Chi-squared</a></li>

<li><a href="Kolmogorov%E2%80%93Smirnov_test" title="Kolmogorov–Smirnov test">Kolmogorov–Smirnov</a></li>

<li><a href="Anderson%E2%80%93Darling_test" title="Anderson–Darling test">Anderson–Darling</a></li>

<li><a href="Lilliefors_test" title="Lilliefors test">Lilliefors</a></li>

<li><a href="Jarque%E2%80%93Bera_test" title="Jarque–Bera test">Jarque–Bera</a></li>

<li><a href="Shapiro%E2%80%93Wilk_test" title="Shapiro–Wilk test">Normality <span style="font-size: 85%;">(Shapiro–Wilk)</span></a></li>

<li><a href="Likelihood-ratio_test" title="Likelihood-ratio test">Likelihood-ratio test</a></li>

<li><a href="Model_selection" title="Model selection">Model selection</a>

<ul><li><a href="Cross-validation_(statistics)" title="Cross-validation (statistics)">Cross validation</a></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Rank_statistics" class="mw-redirect" title="Rank statistics">Rank statistics</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Sample_median" class="mw-redirect" title="Sample median">Sample median</a></li></ul></li>

<li><a href="Wilcoxon_signed-rank_test" title="Wilcoxon signed-rank test">Signed rank <span style="font-size: 85%;">(Wilcoxon)</span></a>

<ul><li><a href="Hodges%E2%80%93Lehmann_estimator" title="Hodges–Lehmann estimator">Hodges–Lehmann estimator</a></li></ul></li>

<li><a href="Mann%E2%80%93Whitney_U_test" title="Mann–Whitney U test">Rank sum <span style="font-size: 85%;">(Mann–Whitney)</span></a></li>

<li><a href="Nonparametric_statistics" title="Nonparametric statistics">Nonparametric</a> <a href="Analysis_of_variance" title="Analysis of variance">anova</a>

<ul><li><a href="Kruskal%E2%80%93Wallis_test" title="Kruskal–Wallis test">1-way <span style="font-size: 85%;">(Kruskal–Wallis)</span></a></li>

<li><a href="Friedman_test" title="Friedman test">2-way <span style="font-size: 85%;">(Friedman)</span></a></li>

<li><a href="Jonckheere's_trend_test" title="Jonckheere's trend test">Ordered alternative <span style="font-size: 85%;">(Jonckheere–Terpstra)</span></a></li></ul></li>

<li><a href="Van_der_Waerden_test" title="Van der Waerden test">Van der Waerden test</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Bayesian_inference" title="Bayesian inference">Bayesian inference</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Bayesian_probability" title="Bayesian probability">Bayesian probability</a>

<ul><li><a href="Prior_probability" title="Prior probability">prior</a></li>

<li><a href="Posterior_probability" title="Posterior probability">posterior</a></li></ul></li>

<li><a href="Credible_interval" title="Credible interval">Credible interval</a></li>

<li><a href="Bayes_factor" title="Bayes factor">Bayes factor</a></li>

<li><a href="Bayes_estimator" title="Bayes estimator">Bayesian estimator</a>

<ul><li><a href="Maximum_a_posteriori_estimation" title="Maximum a posteriori estimation">Maximum posterior estimator</a></li></ul></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="CorrelationRegression_analysis654" style="font-size:114%;margin:0 4em"><div class="hlist"><ul><li><a href="Correlation_and_dependence" class="mw-redirect" title="Correlation and dependence">Correlation</a></li><li><a href="Regression_analysis" title="Regression analysis">Regression analysis</a></li></ul></div></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Correlation_and_dependence" class="mw-redirect" title="Correlation and dependence">Correlation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Pearson_product-moment_correlation_coefficient" class="mw-redirect" title="Pearson product-moment correlation coefficient">Pearson product-moment</a></li>

<li><a href="Partial_correlation" title="Partial correlation">Partial correlation</a></li>

<li><a href="Confounding" title="Confounding">Confounding variable</a></li>

<li><a href="Coefficient_of_determination" title="Coefficient of determination">Coefficient of determination</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Regression_analysis" title="Regression analysis">Regression analysis</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Errors_and_residuals" title="Errors and residuals">Errors and residuals</a></li>

<li><a href="Regression_validation" title="Regression validation">Regression validation</a></li>

<li><a href="Mixed_model" title="Mixed model">Mixed effects models</a></li>

<li><a href="Simultaneous_equations_model" title="Simultaneous equations model">Simultaneous equations models</a></li>

<li><a href="Multivariate_adaptive_regression_splines" class="mw-redirect" title="Multivariate adaptive regression splines">Multivariate adaptive regression splines (MARS)</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Linear_regression" title="Linear regression">Linear regression</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Simple_linear_regression" title="Simple linear regression">Simple linear regression</a></li>

<li><a href="Ordinary_least_squares" title="Ordinary least squares">Ordinary least squares</a></li>

<li><a href="General_linear_model" title="General linear model">General linear model</a></li>

<li><a href="Bayesian_linear_regression" title="Bayesian linear regression">Bayesian regression</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em">Non-standard predictors</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Nonlinear_regression" title="Nonlinear regression">Nonlinear regression</a></li>

<li><a href="Nonparametric_regression" title="Nonparametric regression">Nonparametric</a></li>

<li><a href="Semiparametric_regression" title="Semiparametric regression">Semiparametric</a></li>

<li><a href="Isotonic_regression" title="Isotonic regression">Isotonic</a></li>

<li><a href="Robust_regression" title="Robust regression">Robust</a></li>

<li><a href="Homoscedasticity_and_heteroscedasticity" title="Homoscedasticity and heteroscedasticity">Homoscedasticity and Heteroscedasticity</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Generalized_linear_model" title="Generalized linear model">Generalized linear model</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Exponential_family" title="Exponential family">Exponential families</a></li>

<li><a href="Logistic_regression" title="Logistic regression">Logistic <span style="font-size: 85%;">(Bernoulli)</span></a> / <a href="Binomial_regression" title="Binomial regression">Binomial</a> / <a href="Poisson_regression" title="Poisson regression">Poisson regressions</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Partition_of_sums_of_squares" title="Partition of sums of squares">Partition of variance</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Analysis_of_variance" title="Analysis of variance">Analysis of variance (ANOVA, anova)</a></li>

<li><a href="Analysis_of_covariance" title="Analysis of covariance">Analysis of covariance</a></li>

<li><a href="Multivariate_analysis_of_variance" title="Multivariate analysis of variance">Multivariate ANOVA</a></li>

<li><a href="Degrees_of_freedom_(statistics)" title="Degrees of freedom (statistics)">Degrees of freedom</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Categorical_/_multivariate_/_time-series_/_survival_analysis654" style="font-size:114%;margin:0 4em"><a href="Categorical_variable" title="Categorical variable">Categorical</a> / <a href="Multivariate_statistics" title="Multivariate statistics">multivariate</a> / <a href="Time_series" title="Time series">time-series</a> / <a href="Survival_analysis" title="Survival analysis">survival analysis</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Categorical_variable" title="Categorical variable">Categorical</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cohen's_kappa" title="Cohen's kappa">Cohen's kappa</a></li>

<li><a href="Contingency_table" title="Contingency table">Contingency table</a></li>

<li><a href="Graphical_model" title="Graphical model">Graphical model</a></li>

<li><a href="Poisson_regression" title="Poisson regression">Log-linear model</a></li>

<li><a href="McNemar's_test" title="McNemar's test">McNemar's test</a></li>

<li><a href="Cochran%E2%80%93Mantel%E2%80%93Haenszel_statistics" title="Cochran–Mantel–Haenszel statistics">Cochran–Mantel–Haenszel statistics</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Multivariate_statistics" title="Multivariate statistics">Multivariate</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="General_linear_model" title="General linear model">Regression</a></li>

<li><a href="Multivariate_analysis_of_variance" title="Multivariate analysis of variance">Manova</a></li>

<li><a href="Principal_component_analysis" title="Principal component analysis">Principal components</a></li>

<li><a href="Canonical_correlation" title="Canonical correlation">Canonical correlation</a></li>

<li><a href="Linear_discriminant_analysis" title="Linear discriminant analysis">Discriminant analysis</a></li>

<li><a href="Cluster_analysis" title="Cluster analysis">Cluster analysis</a></li>

<li><a href="Statistical_classification" title="Statistical classification">Classification</a></li>

<li><a href="Structural_equation_modeling" title="Structural equation modeling">Structural equation model</a>

<ul><li><a href="Factor_analysis" title="Factor analysis">Factor analysis</a></li></ul></li>

<li><a href="Multivariate_distribution" class="mw-redirect" title="Multivariate distribution">Multivariate distributions</a>

<ul><li><a href="Elliptical_distribution" title="Elliptical distribution">Elliptical distributions</a>

<ul><li><a href="Multivariate_normal_distribution" title="Multivariate normal distribution">Normal</a></li></ul></li></ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Time_series" title="Time series">Time-series</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;">General</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Decomposition_of_time_series" title="Decomposition of time series">Decomposition</a></li>

<li><a href="Trend_estimation" class="mw-redirect" title="Trend estimation">Trend</a></li>

<li><a href="Stationary_process" title="Stationary process">Stationarity</a></li>

<li><a href="Seasonal_adjustment" title="Seasonal adjustment">Seasonal adjustment</a></li>

<li><a href="Exponential_smoothing" title="Exponential smoothing">Exponential smoothing</a></li>

<li><a href="Cointegration" title="Cointegration">Cointegration</a></li>

<li><a href="Structural_break" title="Structural break">Structural break</a></li>

<li><a href="Granger_causality" title="Granger causality">Granger causality</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;">Specific tests</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Dickey%E2%80%93Fuller_test" title="Dickey–Fuller test">Dickey–Fuller</a></li>

<li><a href="Johansen_test" title="Johansen test">Johansen</a></li>

<li><a href="Ljung%E2%80%93Box_test" title="Ljung–Box test">Q-statistic <span style="font-size: 85%;">(Ljung–Box)</span></a></li>

<li><a href="Durbin%E2%80%93Watson_statistic" title="Durbin–Watson statistic">Durbin–Watson</a></li>

<li><a href="Breusch%E2%80%93Godfrey_test" title="Breusch–Godfrey test">Breusch–Godfrey</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Time_domain" title="Time domain">Time domain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Autocorrelation" title="Autocorrelation">Autocorrelation (ACF)</a>

<ul><li><a href="Partial_autocorrelation_function" title="Partial autocorrelation function">partial (PACF)</a></li></ul></li>

<li><a href="Cross-correlation" title="Cross-correlation">Cross-correlation (XCF)</a></li>

<li><a href="Autoregressive%E2%80%93moving-average_model" class="mw-redirect" title="Autoregressive–moving-average model">ARMA model</a></li>

<li><a href="Box%E2%80%93Jenkins_method" title="Box–Jenkins method">ARIMA model <span style="font-size: 85%;">(Box–Jenkins)</span></a></li>

<li><a href="Autoregressive_conditional_heteroskedasticity" title="Autoregressive conditional heteroskedasticity">Autoregressive conditional heteroskedasticity (ARCH)</a></li>

<li><a href="Vector_autoregression" title="Vector autoregression">Vector autoregression (VAR)</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Frequency_domain" title="Frequency domain">Frequency domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Spectral_density_estimation" title="Spectral density estimation">Spectral density estimation</a></li>

<li><a href="Fourier_analysis" title="Fourier analysis">Fourier analysis</a></li>

<li><a href="Least-squares_spectral_analysis" title="Least-squares spectral analysis">Least-squares spectral analysis</a></li>

<li><a href="Wavelet" title="Wavelet">Wavelet</a></li>

<li><a href="Whittle_likelihood" title="Whittle likelihood">Whittle likelihood</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Survival_analysis" title="Survival analysis">Survival</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Survival_function" title="Survival function">Survival function</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Kaplan%E2%80%93Meier_estimator" title="Kaplan–Meier estimator">Kaplan–Meier estimator (product limit)</a></li>

<li><a href="Proportional_hazards_model" title="Proportional hazards model">Proportional hazards models</a></li>

<li><a href="Accelerated_failure_time_model" title="Accelerated failure time model">Accelerated failure time (AFT) model</a></li>

<li><a href="First-hitting-time_model" title="First-hitting-time model">First hitting time</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Failure_rate" title="Failure rate">Hazard function</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Nelson%E2%80%93Aalen_estimator" title="Nelson–Aalen estimator">Nelson–Aalen estimator</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;">Test</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Applications654" style="font-size:114%;margin:0 4em"><a href="List_of_fields_of_application_of_statistics" title="List of fields of application of statistics">Applications</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Biostatistics" title="Biostatistics">Biostatistics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Bioinformatics" title="Bioinformatics">Bioinformatics</a></li>

<li><a href="Clinical_trial" title="Clinical trial">Clinical trials</a> / <a href="Clinical_study_design" title="Clinical study design">studies</a></li>

<li><a href="Epidemiology" title="Epidemiology">Epidemiology</a></li>

<li><a href="Medical_statistics" title="Medical statistics">Medical statistics</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Engineering_statistics" title="Engineering statistics">Engineering statistics</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Chemometrics" title="Chemometrics">Chemometrics</a></li>

<li><a href="Methods_engineering" title="Methods engineering">Methods engineering</a></li>

<li><a href="Probabilistic_design" title="Probabilistic design">Probabilistic design</a></li>

<li><a href="Statistical_process_control" title="Statistical process control">Process</a> / <a href="Quality_control" title="Quality control">quality control</a></li>

<li><a href="Reliability_engineering" title="Reliability engineering">Reliability</a></li>

<li><a href="System_identification" title="System identification">System identification</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Social_statistics" title="Social statistics">Social statistics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Actuarial_science" title="Actuarial science">Actuarial science</a></li>

<li><a href="Census" title="Census">Census</a></li>

<li><a href="Crime_statistics" title="Crime statistics">Crime statistics</a></li>

<li><a href="Demographic_statistics" title="Demographic statistics">Demography</a></li>

<li><a href="Econometrics" title="Econometrics">Econometrics</a></li>

<li><a href="Jurimetrics" title="Jurimetrics">Jurimetrics</a></li>

<li><a href="National_accounts" title="National accounts">National accounts</a></li>

<li><a href="Official_statistics" title="Official statistics">Official statistics</a></li>

<li><a href="Population_statistics" class="mw-redirect" title="Population statistics">Population statistics</a></li>

<li><a href="Psychometrics" title="Psychometrics">Psychometrics</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Spatial_analysis" title="Spatial analysis">Spatial statistics</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cartography" title="Cartography">Cartography</a></li>

<li><a href="Environmental_statistics" title="Environmental statistics">Environmental statistics</a></li>

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